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- The company aims to be the leader of the bispecific ADC market
ABL Bio (CEO Sang Hoon Lee), a company specializing in bispecific antibodies, today announced that it will attend 'World ADC San Diego' held in USA from November 4th to 7th to introduce its bispecific Antibody Drug Conjugate (ADC) development strategy.
World ADC is the largest ADC specialized event celebrating its 15th anniversary this year, where various participants interested in ADC gather to discuss ADC development strategies and new technologies. ABL Bio was invited to attend this event as a program speaker, and the presentation title is ‘Bispecific ADC as Next Generation of ADC may Overcome Current Clinical Limitations.’ The presentation will include non-clinical data on the bispecific ADC pipeline that ABL Bio is developing.
ABL Bio is developing bispecific ADC as a new driving force for growth into a global bio company. The success of ADC is depending on safe delivering of a larger amount of payload to tumor cells. In the case of bispecific ADC, compared to monoclonal ADC, the payload is delivered to tumor cells more accurately, thereby improving safety and anticancer efficacy, and it is possible to block the tumor cell's evasion mechanism. Tumor cells acquire resistance to anticancer drugs by activating other circuits that can compensate for the blockage of the existing signal transmission systems. However, bispecific ADC can suppress tumor cell's acquisition of resistance by simultaneously targeting two antigens that have a compensatory relationship with each other.
Sang Hoon Lee, CEO of ABL Bio said "as the development of bispecific ADC has become an important topic, we are receiving requests to share ABL Bio's bispecific ADC development strategy at various events. Bispecific ADC market is still in its early stages. We expect to take the leadership in this market through rapid entry. We will do our best to submit INDs for bispecific ADC pipelines by next year by focusing on ongoing non-clinical development of them."
Meanwhile, ABL Bio is developing various clinical and non-clinical assets based on its bispecific antibody platform ‘Grabody’. More than 15 clinical projects for over 7 pipelines, including ABL001, ABL111, ABL503, ABL105, ABL202, ABL301, and ABL103, are underway for different indications in various countries, including the United States, China, Australia, and Korea. ABL’s lead program, ABL001, has been granted Fast Track designation by the U.S. Food and Drug Administration (FDA) to support the rapid development of this new drug candidate. The program recently completed patient enrollment in a Phase 2/3 clinical trial for biliary tract cancer and the top-line data will be disclosed in 2025. Meanwhile, ABL Bio is preparing to initiate clinical trials for ABL104. In addition, ABL Bio is continuously researching and developing several other product candidates, including bispecific antibody-drug conjugates (ADCs).
Note: this is a translated version of the original Korean language document, prepared and provided solely for readers’ convenience. In case of any discrepancy or dispute, the Korean document prevails.