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ABL Bio Announces Strategic Partnership with I-Mab Biopharma of China
- Joint Development of Three Bispecific Antibodies… Acquired Global License outside China - ABL Bio, a Korean Biotech with Industry’s Top-rated Core Technology in Bispecific Antibody and Antibody Drug Conjugate (ADC) July 26, 2018 - ABL Bio formed a strategic partnership with a Chinese biotech firm I-Mab Biopharma (“I-Mab”). With this partnership, ABL Bio will conduct joint research with I-Mab on three Bispecific Antibodies (BsAbs) that combine PD-L1 and an undisclosed material. Including the development costs, licenses in China, Korea, and other countries are expected to be shared under different configurations. In addition, ABL Bio acquired the exclusive global rights to another BsAb in regions excluding Greater China. BsAb shows superior efficacy to monoclonal antibody and due to its low side effects, it reduces pain and stress for the patient. For this reason, BsAb is expected to be the new leading immuno-oncology therapy. Sang Hoon Lee, the founder and CEO of ABL Bio, said, “We are able to develop the first-in-class and the best-in-class BsAb through the partnership with I-Mab, and also to speed up the process of the development of innovative immunotherapy.” He added, “With the strong synergy between the two firms, I expect this partnership to be an exemplary case in the global biotech industry.” CEO Jingwu Zang of I-Mab said, “I am excited to have joined with ABL Bio which has the world’s best technology in BsAb. We will do our best to develop the antibody that will lead the next-generation immuno-oncology therapy.” ABL Bio currently holds core technologies in BsAb and Antibody Drug Conjugate (ADC), the next-generation antibody therapeutics platforms in the area of targeted anti-cancer therapy, immuno-oncology, and Parkinson’s Disease. For the first time in Korea, it is currently in Phase 1 clinical trial of ‘ABL-001’, the first new candidate for BsAb. I-Mab is a leading biotech firm in developing new therapeutics and runs a highly efficient team of world-class research ability. The company is developing the industry’s best biological products in immuno-oncology and immuno-inflammation. It is also preparing to submit multiple IND (Investigational New Drug) applications in order to pursue additional clinical trials and further research in the US and China.
2018-07-26ablbio
ABL Bio Adopts Novel Bispecific Antibody Platform and Two Types of Immuno-Oncology Targete...
- US$220.5 million License-in Agreement on WuXiBody TM Bispecific Antibody Platform and Two Types of Novel Immuno-Oncology Antibody Sequences- Strategic Partnership with WuXi Biologics, Increasing Novel Immuno-Oncology Bispecific Antibody PipelinesSpecific to Patients Unresponsive to Anti-Pd1 and PD-L1 Therapeutics February 25, 2018 - ABL Bio Corporation (“ABL Bio”) announced its license-in agreement with WuXi Biologics(“WuXi Bio”) for WuXiBody TM BsAb platform and two types of novel immuno-oncology antibody sequences forUS$220.5 million. ABL Bio will pay the upfront fee and milestone payments for the development of clinical trials,as well as regulatory and commercial milestone payments. With this agreement, ABL Bio will acquire exclusive rights to the research & development and commercializationof novel Bispecific Antibody (BsAb) that utilizes WuXi Bio’s BsAb platform. As the partner for WuXi Bio, ABL Biowill adopt candidates for novel immune checkpoint inhibitors that are overexpressed among non-responsivegroups to immuno-oncology therapeutics, previously represented by PD-1 and PD-L1. With such adoption, ABLBio will be able to expand its pipeline, a move that is expected to help the company step up as the leader in theglobal BsAb industry. ABL Bio has confirmed in vivo the synergy effect of the combination treatment with PD-1 and PD-L1 immuno-oncology therapy. With this result, the company will develop novel immune checkpoint inhibitor BsAb that willovercome the limits of previous PD-1 therapeutics. WuXiBody TM BsAb platform can assemble all the sequences of monoclonal antibodies into a dual specificstructure, while having low immunogenicity, long half-life in vitro, and superb stability. In addition, it is possible toefficiently and expediently resolve in about 18 months the process of Chemistry, Manufacturing, and Controls(CMC), which is a great challenge in the development of BsAb, thereby significantly lowering the production cost.This platform yields 16g/L with not less than 95% purity, making it the only few ‘best-in-class’ BsAb platform inthe world. Sang Hoon Lee, the founder and CEO of ABL Bio, said, “The reason for recent adoption of BsAb platforms bythe global big pharmas is that one BsAb platform cannot encompass all the targets.” Lee also said, “We decidedto make the adoption with the confidence that th
2018-02-25ablbio