Pipeline

ABL301

HomePipelineABL301

  • Pipeline
    ABL301
  • Program Target
    SNCA x IGF1R
  • Disease Indication
    Parkinson’s Disease
  • Development Stage
    Late-Stage Research
Summary
Propagation of aggregated form of alpha synuclein (α-syn) appears to be critical for etiology of Parkinson’s disease and multiple system atrophy. ABL301 specifically targets aggregated forms of α-syn, potential disease target, Devoid of its normal, monomeric form. Since poor delivery of antibody into the brain is thought to be one of the major obstacles for CNS-related drug development, ABL301 has a shuttle antibody to allow improved delivery of antibody therapeutics into the brain. These dual mechanisms will provide more efficient reach of antibody therapeutics to its target, leading to better therapeutic Efficacy than conventional monoclonal antibody.
Figure from biopharmadeal makers (2017)
좌우스크롤 Figure from biopharmadeal makers (2017)